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Tutorial Abstract

Tutorial 6: Motif Discovery

Title: Bioinformatics methods for identification of functional DNA elements in the Post-ENCODE era
Presenter: Lonnie Welch, Stuckey Professor, School of Elec. Eng. & Computer Science, Biomedical Engineering Program, Molecular and Cellular Biology Program, Ohio University

Attendees are encouraged to bring a laptop with wireless capability.

It is a major accomplishment of modern science that the genomes of human, mouse, rice, mold, influenza, and many other organisms have been sequenced. This knowledge provides us with the blueprints for constructing all of the components that make these organisms! However, the meanings of most regions of the genomic sequences remain a mystery. Thus, an important challenge is to be able to "read" the blueprints.

This tutorial will present an overview of bioinformatics technology that is being to address this challenge. Specifically, the tutorial will (1) provide a taxonomic and experimental characterization of bioinformatics methods for discovering functional elements in genomic sequences, (2) teach attendees how to use several bioinformatics tools for identifying putative functional elements in DNA sequences, (3) highlight important outcomes of the ENCyclopedia Of DNA Elements (ENCODE) project, and (4) present opportunities and challenges related to solving the mysteries of the genomes.

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